Influence of perineural invasion in predicting overall survival and disease-free survival in patients With locally advanced gastric cancer

 

Highlights

• •Perineural invasion (PNI) is an important pathologic feature of neoplasms.
• •Influence of PNI is used for staging in different types of tumors.
• •Prognosis of gastric cancer patients is shown to be influenced by PNI.
• •PNI should be considered to plan the best systemic treatment after surgery

Background

The aim of the present study was to evaluate the prognostic significance of perineural invasion (PNI) in locally advanced gastric cancer patients who underwent D2 gastrectomy and adjuvant chemotherapy.

Conclusions

PNI and T stage and positive lymph nodes are independent markers of poor prognosis in patients with gastric cancer. PNI should be incorporated in the postoperative staging system for planning follow-up after surgery and in our opinion to propose more aggressive postoperative therapies in PNI-positive patients.

http://www.americanjournalofsurgery.com/article/S0002-9610(16)30367-1/abstract