Pretreatment Neutrophil to Lymphocyte Ratio Independently Predicts Disease-specific Survival in Resectable Gastroesophageal Junction and Gastric Adenocarcinoma

Wang, Sam C. MD; Chou, Joanne F. MPH; Strong, Vivian E. MD; Brennan, Murray F. MD; Capanu, Marinela PhD; Coit, Daniel G. MD

Annals of Surgery: February 2016 - Volume 263 - Issue 2 - p 292–297

doi: 10.1097/SLA.0000000000001189

Original Articles

Objective: Preoperative methods to estimate disease-specific survival (DSS) for resectable gastroesophageal (GE) junction and gastric adenocarcinoma are limited. We evaluated the relationship between DSS and pretreatment neutrophil to lymphocyte ratio (NLR).

Background: The patient's inflammatory state is thought to be associated with oncologic outcomes, and NLR has been used as a simple and convenient marker for the systemic inflammatory response. Previous studies have suggested that NLR is associated with cancer-specific outcomes.

Conclusions: In patients with resectable GE junction and gastric adenocarcinoma, pretreatment NLR independently predicts DSS. This and other clinical variables can be used in conjunction with cross-sectional imaging and endoscopic ultrasound as part of the preoperative risk stratification process.

http://journals.lww.com/annalsofsurgery/Abstract/2016/02000/Pretreatment_Neutrophil_to_Lymphocyte_Ratio.16.aspx