Individualized Venous Thromboembolism Risk Stratification Using the 2005 Caprini Score to Identify the Benefits and Harms of Chemoprophylaxis in Surgical Patients: A Meta-analysis

Pannucci, Christopher J. MD, MS^*; Swistun, Lukasz MD^†; MacDonald, John K. MA^‡; Henke, Peter K. MD^§; Brooke, Benjamin S. MD, PhD^¶

Annals of Surgery: June 2017 - Volume 265 - Issue 6 - p 1094–1103

doi: 10.1097/SLA.0000000000002126

Meta-Analyses

Objective: We performed a meta-analysis to investigate benefits and harms of chemoprophylaxis among surgical patients individually risk stratified for venous thromboembolism (VTE) using Caprini scores.

Summary of Background Data: Individualized VTE risk stratification may identify high risk surgical patients who benefit from peri-operative chemoprophylaxis.

Conclusions: The benefit of peri-operative VTE chemoprophylaxis was only found among surgical patients with Caprini scores ≥7. Precision medicine using individualized VTE risk stratification helps ensure that chemoprophylaxis is used only in appropriate surgical patients and may minimize bleeding complications.

http://journals.lww.com/annalsofsurgery/Abstract/2017/06000/Individualized_Venous_Thromboembolism_Risk.12.aspx